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In the mitochondria, the production of acetate from acetaldehyde leads to increased levels of acetyl-CoA
Cruciani et al
Surprisingly, extensive down-regulation of miRNAs such as miR-27a, miR-34a, miR-142-5p, and miR-7, involved in cytoprotection against OS and some of them also capable of targeting Nrf2 directly, has been detected in the muscle, CSF, MN progenitors, and blood as well as in post mortem specimens (brain, brain stem, and the spinal cord) of both sALS and fALS patients, unlike healthy controls [258,259,260,261,262]
Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives
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